First student at the Geneva conservatory, Dominique Reymond then studied under Antoine Vitez at Chaillot. She was a renowned theatre actress, having worked with Sobel, Grüber and Lassalle, and only made her first screen appearance in 1984 in "Pinot simple flic", followed by roles in films by Dupeyron, Chabrol and Garrel ("The Birth of Love" in 1993). The general public discovered her as a courageous attentive mother in 1996 in "Will It Snow for Christmas?", a rural fairy tale by Sandrine Veysset. She won the Best Actress award at the Paris Film Festival for her role.
With her deep voice and elegant silhouette, Dominique Reymond often assumed the role of a mother ("Sade", "Almost Nothing"), but also roles in more shocking films such as "In My Skin" by Marina De Van, the experimental "Process" or "Ma mere" adapted for the screen by Christophe Honore from the book by Bataille. She appeared twice in films by Olivier Assayas, as Berling's sister in "Les Destinées sentimentales" and as an executive business woman in the thriller "Demonlover". She also played the wife of unfaithful Jacques Perrin in "Hell" by Danis Tanovic (2005) before working with Sandrine Veysset ten years later ("Once Upon a Tomorrow").