Muriel Robin grew up along side her two sisters, Martine and Nidia, in the family shoe store in St Etienne where her parents had relocated in 1960. She dreamt of becoming a singer. Twice she tried to get her secondary school diploma but to no avail and so decided to work in her parents shop in 1975. Two years later she left for Paris and began classes at Cours Florent. She was accepted on her first attempt into the Conservatory of Dramatic Arts under the direction of Michel Bouquet at the time. After having received her diploma in 1981, she joined the "Petit théâtre de Bouvard" troupe and shortly after she had her first role on stage in the play entitled "Double Foyer" in 1985.
She began to write, met Pierre Palmade in 1988 and the two collaborated on several one-woman shows that became her trademark. A year before, Muriel Robin had taken on Valerie Lemercier's character in "The Corridors of Time: The Visitors II" marking her first film appearance. In the year 2000, she decided to put an end to stand-up comedy shows and plunge into the world of filmmaking, obtaining a lead role in Mehdi Charef's "Marie-Line". Next was the voice of the animated character Becassine in "Becassine, le trésor Viking". Often cast for her comic talent, she landed the lead role in the dramatic comedy by Coline Serreau, "Saint-Jacques... La Mecque" and then joined the phenomenal cast in "A Day at the Museum", inciting bursts of laughter from the audience at each appearance in the film. Yet, on screen she appears to be the most "natural" in two documentaries: "Le Bal des actrices" by Maïwenn and the moving TV documentary focusing on Annie Girardot in which Muriel Robin touches our heart when talking about her friend's battle against Alzheimer disease.