Stéphane Villiers is thirty. His life is a success. Between break-ups and new affairs, poker games and his career as a hospital paediatrician, he lives too fast, as if trying to exhaust himself or flee something. On returning home early one morning, after thirty-six hours without sleep, he finds a little twelve-year-old girl, Eva, dozing in the lobby of his building. She claims to have run away from home, that she is a battered child... He agrees to put her up for the night. Eva moves into Stéphane's life with amazing self-assurance, disarming freshness and insolence. Stéphane, touched and troubled, gets caught up on the game. Eva gives him back his childhood dreams. She urges him to question everything. When he realizes that she is ill, he even challenges the medical authorities and risks his career to give her a new treatment. He is ready to reconsider his whole life for Eva. By asking him to cure her, it's as if the little girl is teaching him to live up to his dreams...
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After his screen debut as Patrice Chéreau's "L'Homme blessé," Jean-Hugues Anglade appeared alongside Michel Piccoli in Richard Dembo's "Dangerous Moves". Luc Besson then offered him the part of the Roller in "Subway." Then came Zorg in Jean-Jacques Beineix's "Betty Blue". Among other awards, the film won the top prize at the Montreal Festival, competed for the Best Foreign Film Oscar and brought Jean-Hugues Anglade a best Actor César nomination. After starring alongside Nastassja Kinski in Jacques Deray's "Maladie d’amour," he acted for the first time in English in Alain Corneau's "Nocturne Indien" (Best Actor César nomination). This was followed by Luc Besson's "Nikita", Michel Deville's "One Summer Night in Town," Arnaud Sélignac's "Gawin," Roberto Faenza's "Années d’enfance" (winner of three David di Donatello awards in Italy), Roger Avary's "Killing Zoé" (winner at the Ubary Festival in Japan), and Elie Chouraqui's "les Marmottes". Shortly afterwards, he appeared in Patrice Chéreau's "Queen Margot" and won the Best Supporting Actor César for his performance as Charles IX. Alexandre Arcady is the first director to offer him a comic role in "Dis-moi oui".