Daughter of actors Alain Doutey and Arielle Semenoff.
Having grown up in a family of actors, Melanie Doutey enrolled at Cours Perimony in order to pursue the actor's craft herself, which began in the year 2000 in the dramatic comedy "Les Gens qui s'aiment" by Jean-Charles Tacchella. She continued her studies at the National Conservatory of Dramatic Arts in Paris and starred in "The Warrior's Brother" (2002) along with Guillaume Canet and Vincent Lindon. Her first leading role followed the next year in "Leïla" by Gabriel Axel.
Taken by her charm, Claude Chabrol cast her as the ingénue Michele in the acclaimed "The Flower of Evil" (2003). Her partner in real life, Gilles Lellouche shared the billing in "Narco: The Secret Adventures of Gustave Klopp" (2004), "On va s'aimer" (2006), "My Place in the Sun" (2007) and "A Spot of Bother" (2010). Her TV character Clara Sheller, a 30ish young woman looking for her ideal man, cinched her popularity. Following a trip to Spain for the thriller "The Wolf" by Miguel Courtois, Melanie Doutey appeared in a period piece inspired by Alfred de Musset, "Never Say... Never!". Her role as Cecile won her a nomination for the Most Promising Young Actress at the Cesars in 2006 (her second nomination in the category, along with "The Warrior's Brother").
After a couple of thrillers, "Fair Play" (2006) & "President", she took a dip in a lighter comedy entitled "Tonight I'll Sleep at Yours" (2007) opposite Jean-Paul Rouve and Kad Merad, the later with whom she also starred in "RTT" in 2009. That same year, she joined the prestigious cast of "Bal des actrices" by Maïwenn and became a business woman in "Nothing Personal", first feature by Mathias Gokalp.